Senior Researcher at Moscow State University Alexander Tyshkovsky is sure that in order to protect the human body from coronavirus, it is necessary to inject additional copies of the ACE2 protein into the infected person, reports Rossiyskaya Gazeta . Experiments with cell cultures have proven the effectiveness of the approach. Tyszkowski notes: “As we have already seen, the SARS-CoV-2 coronavirus mutates, albeit not as quickly as the influenza virus. This means that over time it will leave the immunity radar and be able to infect us with renewed vigor. through which the virus enters the human body is the ACE2 protein located on the cell surface.
The spike protein SARS-CoV-2 happily binds to this receptor, causing the gate to open, allowing the virus to enter. It turns out that ACE2 is our weak point, which the coronavirus has successfully used over and over again. But what if you turn this disadvantage into an advantage? If you introduce additional copies of the ACE2 protein into the blood of an infected patient, then the added receptors, like antibodies, will bind the spines of the coronavirus and prevent it from attacking our cells. We literally catch the virus on live bait: in search of doors to the cage, over and over again he will stumble upon the mousetraps we have placed.
The safety of using ACE2 in healthy people was confirmed by the results of the first phase of trials back in 2013. Then they wanted to use the protein to treat another respiratory disease. The second phase of ACE2's COVID-19 trials has already begun. Results are expected in December this year. "
Adding ACE2 protein neutralized SARS-CoV-2. ACE2 is known to be involved in the breakdown of angiotensin II. This compound causes increased blood pressure, inflammation and cytokine storm. Therefore, additional copies of ACE2 will help reduce angiotensin levels II, relieving the symptoms of the disease